| Pair Name | 2,3,5,6-Tetramethylpyrazine, Doxorubicin | ||
| Phytochemical Name | 2,3,5,6-Tetramethylpyrazine (PubChem CID: 14296 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | 2,3,5,6-Tetramethylpyrazine, Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Mitochondria-mediated apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Down-regulation | Expression | CCNA2 | hsa890 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Down-regulation | Phosphorylation | EGFR | hsa1956 | |
| Down-regulation | Expression | PIK3CA | hsa5290 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| K562/A02 | Blast phase chronic myelogenous leukemia | Homo sapiens (Human) | CVCL_0368 | |
| Result | DLJ14 and Adr combination treatment may inhibit proliferation of Adr-resistant human breast cancer cells through inhibition of the EGFR/PI3K/Akt survival pathway and induction of apoptosis via the mitochondrial-mediated apoptosis pathway. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combination treatment of ligustrazine piperazine derivate DLJ14 and adriamycin inhibits progression of resistant breast cancer through inhibition of the EGFR/PI3K/Akt survival pathway and induction of apoptosis. Drug Discov Ther. 2014 Feb;8(1):33-41. doi: 10.5582/ddt.8.33. | Click |
